🔬 A new tool for Glioblastoma surgery

We are happy to share the latest publication by Meedie Ali from the group of Laura Mezzanotte at Erasmus MC Cancer Institute, which uses the Kratoscope for 3D ex vivo imaging in a glioblastoma (GBM) model. 

GBM is one of the most aggressive brain tumors, with high recurrence rates due to the difficulty of detecting and removing invasive tumor margins during surgery.

The paper introduces a micellar nanoprobe (mFA-ICG) that enables near-infrared (NIR) fluorescence image-guided delineation of GBM margins.

✨ This work illustrates how the Kratoscope can help researchers to: 

• Bridge the technological gap between in vivo imaging and histology

• Reconstruct the whole brain in 3D and measure tumor volume 

• Visualise 3D near infrared fluorescence alongside tissue architecture

• Compare 3D fluorescence with MRI imaging to confirm co-localisation

📄 The full article is accessible here: https://doi.org/10.1016/j.phrs.2025.107881.

Fig 3. from the publication: In- and ex vivo imaging and 3D cryo-fluorescence tomography of FA-ICG in orthotopic patient-derived glioblastoma model

👏 Congratulations to all the authors on this exciting advancement!

The Kratoscope is a serial block face imaging system, developed and sold by Kaer Labs to image organs ex vivo with or without labeling, with the possibility of collecting slices for additional imaging, microscopy, histology or analysis.